Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors
Identifieur interne : 003B68 ( Main/Exploration ); précédent : 003B67; suivant : 003B69Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors
Auteurs : Hagop M. Kantarjian [États-Unis] ; Jorge E. Cortes [États-Unis] ; Dong-Wook Kim [Corée du Sud] ; H. Jean Khoury [États-Unis] ; Tim H. Brümmendorf [Allemagne] ; Kimmo Porkka [Finlande] ; Giovanni Martinelli [Italie] ; Simon Durrant [Australie] ; Eric Leip ; Virginia Kelly ; Kathleen Turnbull [États-Unis] ; Nadine Besson [France] ; Carlo Gambacorti-Passerini [Italie]Source :
- Blood [ 0006-4971 ] ; 2014.
Abstract
Bosutinib had manageable toxicity and acceptable tolerability, with adverse events distinct from that of other tyrosine kinase inhibitors. Adverse events were primarily characterized by early-onset gastrointestinal events that were low grade, transient, and manageable.
Url:
DOI: 10.1182/blood-2013-07-513937
PubMed: 24345751
PubMed Central: 4467890
Affiliations:
- Allemagne, Australie, Corée du Sud, Finlande, France, Italie, États-Unis
- District de Cologne, Géorgie (États-Unis), Hambourg, Massachusetts, Rhénanie-du-Nord-Westphalie, Région capitale de Séoul, Texas, Île-de-France
- Aix-la-Chapelle, Hambourg, Paris, Séoul
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Le document en format XML
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Kantarjian</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Cortes, Jorge E" sort="Cortes, Jorge E" uniqKey="Cortes J" first="Jorge E." last="Cortes">Jorge E. Cortes</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong-Wook" last="Kim">Dong-Wook Kim</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Hematology, Seoul St. Mary’s Hospital, Seoul, South Korea;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Hematology, Seoul St. Mary’s Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Brummendorf, Tim H" sort="Brummendorf, Tim H" uniqKey="Brummendorf T" first="Tim H." last="Brümmendorf">Tim H. Brümmendorf</name><affiliation wicri:level="3"><nlm:aff id="aff4">Hematology, Oncology, and Stem Cell Transplantation, Universitätsklinikum Aachen, Rheinisch-Westfaelische Technische Hochschule Aachen, Aachen, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hematology, Oncology, and Stem Cell Transplantation, Universitätsklinikum Aachen, Rheinisch-Westfaelische Technische Hochschule Aachen, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5">Hematology, Oncology, and Stem Cell Transplantation, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hematology, Oncology, and Stem Cell Transplantation, Universitätsklinikum Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Porkka, Kimmo" sort="Porkka, Kimmo" uniqKey="Porkka K" first="Kimmo" last="Porkka">Kimmo Porkka</name><affiliation wicri:level="1"><nlm:aff id="aff6">Division of Hematology, Helsinki University Central Hospital, Helsinki, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Division of Hematology, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Durrant, Simon" sort="Durrant, Simon" uniqKey="Durrant S" first="Simon" last="Durrant">Simon Durrant</name><affiliation wicri:level="1"><nlm:aff id="aff8">Bone Marrow Transplant Unit, Royal Brisbane Hospital, Herston, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Bone Marrow Transplant Unit, Royal Brisbane Hospital, Herston</wicri:regionArea><wicri:noRegion>Herston</wicri:noRegion></affiliation></author><author><name sortKey="Leip, Eric" sort="Leip, Eric" uniqKey="Leip E" first="Eric" last="Leip">Eric Leip</name><affiliation><nlm:aff id="aff9">Oncology Clinical Statistics,</nlm:aff></affiliation></author><author><name sortKey="Kelly, Virginia" sort="Kelly, Virginia" uniqKey="Kelly V" first="Virginia" last="Kelly">Virginia Kelly</name><affiliation><nlm:aff wicri:cut=", and" id="aff10">Oncology Clinical Research</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Kathleen" sort="Turnbull, Kathleen" uniqKey="Turnbull K" first="Kathleen" last="Turnbull">Kathleen Turnbull</name><affiliation wicri:level="2"><nlm:aff id="aff11">Oncology Clinical Development, Pfizer Inc., Cambridge, MA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Oncology Clinical Development, Pfizer Inc., Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Besson, Nadine" sort="Besson, Nadine" uniqKey="Besson N" first="Nadine" last="Besson">Nadine Besson</name><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff12">Pfizer Global Research and Development, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pfizer Global Research and Development, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gambacorti Passerini, Carlo" sort="Gambacorti Passerini, Carlo" uniqKey="Gambacorti Passerini C" first="Carlo" last="Gambacorti-Passerini">Carlo Gambacorti-Passerini</name><affiliation wicri:level="1"><nlm:aff id="aff13">Clinical Research Unit, University of Milano-Bicocca, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Research Unit, University of Milano-Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Bosutinib had manageable toxicity and acceptable tolerability, with adverse events distinct from that of other tyrosine kinase inhibitors.</p></list-item><list-item><p>Adverse events were primarily characterized by early-onset gastrointestinal events that were low grade, transient, and manageable.</p></list-item></list></p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Corée du Sud</li><li>Finlande</li><li>France</li><li>Italie</li><li>États-Unis</li></country><region><li>District de Cologne</li><li>Géorgie (États-Unis)</li><li>Hambourg</li><li>Massachusetts</li><li>Rhénanie-du-Nord-Westphalie</li><li>Région capitale de Séoul</li><li>Texas</li><li>Île-de-France</li></region><settlement><li>Aix-la-Chapelle</li><li>Hambourg</li><li>Paris</li><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Kelly, Virginia" sort="Kelly, Virginia" uniqKey="Kelly V" first="Virginia" last="Kelly">Virginia Kelly</name><name sortKey="Leip, Eric" sort="Leip, Eric" uniqKey="Leip E" first="Eric" last="Leip">Eric Leip</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name></region><name sortKey="Cortes, Jorge E" sort="Cortes, Jorge E" uniqKey="Cortes J" first="Jorge E." last="Cortes">Jorge E. Cortes</name><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name><name sortKey="Turnbull, Kathleen" sort="Turnbull, Kathleen" uniqKey="Turnbull K" first="Kathleen" last="Turnbull">Kathleen Turnbull</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong-Wook" last="Kim">Dong-Wook Kim</name></region></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Brummendorf, Tim H" sort="Brummendorf, Tim H" uniqKey="Brummendorf T" first="Tim H." last="Brümmendorf">Tim H. Brümmendorf</name></region><name sortKey="Brummendorf, Tim H" sort="Brummendorf, Tim H" uniqKey="Brummendorf T" first="Tim H." last="Brümmendorf">Tim H. Brümmendorf</name></country><country name="Finlande"><noRegion><name sortKey="Porkka, Kimmo" sort="Porkka, Kimmo" uniqKey="Porkka K" first="Kimmo" last="Porkka">Kimmo Porkka</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name></noRegion><name sortKey="Gambacorti Passerini, Carlo" sort="Gambacorti Passerini, Carlo" uniqKey="Gambacorti Passerini C" first="Carlo" last="Gambacorti-Passerini">Carlo Gambacorti-Passerini</name></country><country name="Australie"><noRegion><name sortKey="Durrant, Simon" sort="Durrant, Simon" uniqKey="Durrant S" first="Simon" last="Durrant">Simon Durrant</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Besson, Nadine" sort="Besson, Nadine" uniqKey="Besson N" first="Nadine" last="Besson">Nadine Besson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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